Is Upstream Bio, Inc. UPB stock Halal to invest in?

No, as of September 2026, Upstream Bio, Inc. stock (UPB) is not currently classified as a Shariah compliant stock. This verdict follows the screening methodology of AAOIFI (the Accounting and Auditing Organization for Islamic Financial Institutions), whose Shariah Standard No. 21 is the leading global benchmark for screening Halal stocks. To qualify as Halal under this standard, a company must keep non-permissible income below 5% of total revenue, keep both interest-bearing investments and interest-bearing debt below 30% of market capitalisation, and have no impermissible preference share structure. Upstream Bio, Inc. currently does not meet the threshold for the non-permissible income and interest-bearing investments screens. Because screenings are refreshed monthly as new financial reports are published, a non-compliant stock can regain compliant status if its financial structure changes. You can track the latest status of Upstream Bio, Inc. and discover Shariah compliant alternatives among the Halal stocks in the Tabadulat app.

How often is Upstream Bio, Inc. UPB reviewed for Shariah compliance?

Tabadulat reviews Upstream Bio, Inc. UPB for Shariah compliance every month. Each review applies the AAOIFI Shariah Standard No. 21 methodology, screening the company's business activities, non-permissible income, interest-bearing investments, interest-bearing debt, and preference shares, against the company's latest available financial data. The process operates under the direct supervision of Tabadulat's dedicated Shariah Supervisory Board of Islamic finance scholars. Because compliance depends on financial ratios that move with market capitalisation and reported results, a stock's status can change from one review to the next. Monthly screening ensures the status shown for Upstream Bio, Inc. reflects current financial data rather than an outdated assessment, and Tabadulat app users are notified if a holding in their portfolio becomes non-compliant.

Does Upstream Bio, Inc. UPB pass the AAOIFI Non Permissible Income criteria?

No, as of September 2026, Upstream Bio, Inc. stock (UPB) does not pass the AAOIFI non-permissible income screen. Under AAOIFI Shariah Standard No. 21, income from impermissible sources (such as interest or Riba, conventional financial services, alcohol, gambling, or tobacco) must remain below 5% of a company's total revenue. Upstream Bio, Inc.'s income from non-permissible sources currently exceeds this 5% ceiling, which makes the stock non-compliant on this criterion regardless of how it performs on the other screens. The screen is reassessed monthly, so the status can change when the company releases new financial statements.

Does Upstream Bio, Inc. UPB pass the AAOIFI Interest Bearing Investments criteria?

No, as of September 2026, Upstream Bio, Inc. stock (UPB) does not pass the AAOIFI interest-bearing investments screen. Under AAOIFI Shariah Standard No. 21, the cash a company places in interest-earning instruments (such as conventional deposits, bonds, treasury bills and money-market funds) must remain below 30% of its market capitalisation. Upstream Bio, Inc.'s interest-bearing investments currently exceed this 30% limit, meaning too large a share of the company's value derives from Riba-based instruments for the stock to qualify as Halal on this criterion. The ratio moves with both the balance sheet and the share price, and is reassessed monthly.

Does Upstream Bio, Inc. UPB pass the AAOIFI Interest Bearing Debt criteria?

Yes, as of September 2026, Upstream Bio, Inc. stock (UPB) passes the AAOIFI interest-bearing debt screen. AAOIFI tolerates some conventional borrowing but draws the line at 30% of market capitalisation. On the latest data, Upstream Bio, Inc.'s interest-bearing debt stays below the line. Because market capitalisation changes daily, a company's debt ratio can drift toward or away from the limit even without new borrowing, which is why this screen is reassessed every month.

What is the dividend purification factor for Upstream Bio, Inc. UPB stock?

Upstream Bio, Inc. (UPB) is currently classified as not Shariah compliant, so no dividend purification factor applies, because purification factors are calculated only for stocks that pass the AAOIFI screens. Purification (Tazkiyah) is the practice of donating to charity the small portion of dividend income that stems from incidental non-permissible sources, such as interest earned on a compliant company's cash deposits. For non-compliant stocks the issue is not purification but eligibility: under AAOIFI Shariah Standard No. 21 the stock does not currently qualify as a Halal investment. If Upstream Bio, Inc. returns to compliance in a future monthly screening, its purification factor will be published alongside its updated status in the Tabadulat app.

Does Upstream Bio, Inc. UPB pass the AAOIFI Preference Share screen?

Yes, as of September 2026, Upstream Bio, Inc. stock (UPB) passes the AAOIFI preference share screen. AAOIFI Shariah Standard No. 21 prohibits investing in preference shares because they grant holders guaranteed or priority rights to dividends and capital ahead of ordinary shareholders, a structure that conflicts with the Shariah principle that investors should share profit and loss in proportion to their ownership. Upstream Bio, Inc. has no impermissible preference share structure affecting its ordinary shares, so the stock is compliant on this criterion. Like all AAOIFI screens, this is verified in each monthly review.

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Is Upstream Bio (UPB) stock Halal?

NASDAQ

Shariah-Compliant

Not Shariah

September 2026 AAOIFI screening result for Upstream Bio, Inc. (UPB): non-permissible income, fail. Interest-bearing investments, fail. Interest-bearing debt, pass. Preference shares, pass. Upstream Bio, Inc. is not currently Shariah compliant. Re-screened monthly against AAOIFI Shariah Standard No. 21.

Sector:

Healthcare

Industry:

Biotechnology

Employees:

Website:

https://upstreambio.com

Market cap:

$355M

P/E ratio:

Dividend yield:

52-week range:

$5.79 - $33.68

Data as of:

3 September 2026

Screening history:

September 2026: FAIL

Upstream Bio operates within the biotechnology sector, focusing on the development of innovative therapeutic solutions for advanced immunological diseases. The company aims to address unmet medical needs by leveraging cutting-edge scientific research and technology advancements. Upstream Bio emphasizes the discovery and development of novel biological therapies with the potential to significantly improve patient outcomes in conditions that currently have limited or ineffective treatments. Before any of that matters to a Muslim investor, one question comes first: is Upstream Bio stock Halal?

Is Upstream Bio Shariah compliant?

The Shariah case on a technology company like Upstream Bio is rarely about the product. What AAOIFI Shariah Standard No. 21 examines is the money around the product: cash parked in instruments that earn Riba, borrowing measured against a market capitalisation that moves daily, and any incidental income from sources Islam prohibits, which must stay below 5% of revenue.

Does Upstream Bio pass the business activity test?

The activity screen is only part of the picture this month: Upstream Bio currently fails the non-permissible income and interest-bearing investments screens, so the overall verdict is not compliant regardless of the business itself. The watch item for technology names is incidental: cash returns and platform content can carry impermissible elements, which AAOIFI tolerates only below the thresholds.

Is Upstream Bio's income Halal?

No. Upstream Bio's income from impermissible sources currently exceeds AAOIFI's 5% revenue ceiling, which makes the stock non-compliant on this screen regardless of the others. The screen is reassessed monthly, so the status can change when new financial statements arrive.

Does Upstream Bio meet AAOIFI's debt and investment ratio requirements?

Not in full. Interest bearing investments currently exceed the 30% cap, while the other ratio stays within it. One breach is enough to fail the screening; the ratios are reassessed monthly under our Shariah Supervisory Board.

Tabadulat is an ADGM regulated brokerage whose license covers Shari'a Compliant Regulated Activities, as the FSRA permission names them. New to the terminology? Gharar and Maysir, Sukuk, Zakat and purification are all explained in plain English.

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